5 EASY FACTS ABOUT PKRRATING DESCRIBED

The activated enzyme then phosphorylates its important substrate, the translational initiation element eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to a conserved household of 4 protein kinases (PKR, PERK, GCN2, HRI) that all phosphorylate eIF2α in reaction to unique stimuli12, triggering the integrated tension re